Cushing's patients have a lot of problems with fluid regulation. Since the hypothalamic-pituitary-adrenal (HPA) axis is involved in the control of body fluid, it isn't surprising glucocorticoids are involved. This research indicates glucocorticoids play a role.
The data presented here suggest that glucocorticoids are not only involved in the mechanisms underlying the fast release but also in the transcriptional events that lead to decreased synthesis and secretion of these neuropeptides, particularly oxytocin, under diverse experimental conditions of altered fluid volume and tonicity.
To read more, the full-text article may be found here:
Central actions of glucocorticoids in the control of body fluid homeostasis: Review
S.G. Ruginsk, A. Lopes da Silva, R.R. Ventura, L.L.K. Elias, J. Antunes-Rodrigues (2009). Central actions of glucocorticoids in the control of body fluid homeostasis: Review Brazilian Journal of Medical and Biological Research, 42 (1) DOI: 10.1590/S0100-879X2009000100010
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