According to a study reported on MedPage Today, the method/route of replacing estrogen may affect the amount of growth hormone (GH) needed as a replacement therapy. Many folks with Cushing's are also GH deficient and take GH replacement shots. These main points were made to clinicians:
This study has not been published in a peer-reviewed journal yet, but was presented at a conference.
Transdermal (vs. oral) estrogen replacement showed a significantly lower dosage need for GH replacement. Also, "there were modest trends suggesting lower triglycerides and LDL cholesterol with the transdermal estrogens."
- Explain to interested patients that estrogen replacement in women taking growth hormone supplementation may affect the growth hormone dosing requirement.
- Explain that this study did not find that any particular type of estrogen replacement was unsafe.
- Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered preliminary until published in a peer-reviewed journal.
This study has not been published in a peer-reviewed journal yet, but was presented at a conference.
